Three concordant findings — what your reading looks like.
An anonymised sample showing how the five-domain engine surfaces findings only when the methods agree. Concordant findings are actionable; managed findings are tracked but already mitigated.
MTHFR
Concordant · actionable5-methodC677T (rs1801133)
Pathogenic variant — MTHFR deficiency, hyperhomocysteinemia.
rs1801133 ↔ elevated homocysteine, p = 2.3 × 10⁻⁸⁹.
Methylation-cycle PRS at 82nd percentile.
PhenoAge clock +1.8 years vs chronological.
Hcy 18.2 µmol/L — 2.0× above optimal threshold.
Methylfolate (5-MTHF) 800 µg/day + Methylcobalamin 1 000 µg/day.
APOE
Concordant · actionable4-methodε3/ε4 (rs429358)
ε4 risk allele — late-onset Alzheimer's + cardiovascular disease.
rs429358 ↔ elevated ApoB, p = 1.2 × 10⁻¹⁵⁶.
Cardiovascular PRS at 91st percentile.
Mother diagnosed with Alzheimer's at 67.
Omega-3 (EPA/DHA) 2 000 mg/day + Mediterranean lipid program. Discuss statin with physician.
VDR
Managed · stable3-methodFokI (rs2228570)
Reduced VDR receptor activity — increased supplementation need.
rs2228570 ↔ vitamin D insufficiency, p = 4.1 × 10⁻¹².
25(OH)D 52 ng/mL — within target on current supplementation.
Continue Vitamin D3 4 000 IU/day. Monitor seasonally.
Anonymised sample · educational use · not a substitute for clinical care